Biotech Manufacturing

In addition to the business challenges faced by biotech companies, you are also faced with managing complex manufacturing processes. Activities include material tracking/genealogy, managing bills of material and work instructions, asset management, lab systems integration, production dispatching and execution, and regulatory reporting. Honeywell’s biotech solutions integrate best practices in key areas such as process control, Manufacturing Execution Systems (MES) and environmental monitoring to efficiently meet these requirements. Honeywell developed the Manufacturing Control System (MCS), combining the Experion® Process Knowledge System (PKS) and POMSnet to provide an architecture for managing biotech processes in a single, unified environment which provides a single solution for production management, process automation and reporting. This unified MCS design utilizes the strengths of POMSnet for material management and plant floor applications, and Experion to incorporate the latest advancements in process control technology in a way that is most beneficial to operational objectives. Tight integration of Experion and POMSnet allows biotech manufacturers to move beyond manual functionality and leverage all of the robust capabilities the two systems have to offer. These include: Electronic work instruction execution and workflows Material reporting Asset management Laboratory data logging Production dispatching Electronic Batch Record (EBR) management Honeywell’s understanding of the pharmaceutical and biotech industries comes from successful projects with many major suppliers. From Experion to POMSnet, Honeywell’s solutions are built for biotech with features specifically designed to meet rigid regulatory requirements. Honeywell’s distributed systems architecture (DSA) allows seamless integration of multiple Experion systems with minimum effort. Share history, alarms, real-time data, messages and more with no data duplication minimizing validation requirements. Qualification and Version Control System (QVCS) eases system configuration management and management of change by providing a means to electronically maintain the lifecycle and change history of Experion control modules.  21 CFR Part 11 compliance features to help ensure compliance. Controller-based batch unit operations optimize cycle times and take advantage of the robustness of Experion controllers. Honeywell’s portfolio of security tools includes cyber security options, biometric access points and video control units, all of which are integrated into the Experion system. The integration of Experion PKS and POMSnet provides a single operating environment, making it easy to create and manage recipes. For activities which do not involve control system interaction, POMSnet provides work instructions using either a classic list format or graphical flowchart format. Other functions specific to the needs of the biotech industry included in POMSnet are: Aliquot preparation Blend labeling Volume dispensing Utility materials Sample collection support for multiple containers and multiple results Advanced material properties like max usage time, material contact rules, use cycles and max time at storage condition Cell culture data management Target seed density for bioreactors  Assembly Creation and Management  Control system instruction lists